Precursor TST

Testosterone begins to decline after age 30. Aromatase can convert this hormone into an inactive hormone (a process called aromatisation) or into oestrogen, causing a loss of physical and mental vitality in men.

To counter these effects, we have collected natural elements capable of promoting increased endogenous secretion of testosterone, while optimising its health benefits.

Testosterone is the male hormone par excellence, it helps to develop muscle mass and promotes stamina, charisma and competitiveness. Linked to male physical and psychological development, it is a hormone coveted for its benefits. Optimal secretion of testosterone ensures good health, a powerful immune system, physical strength and above-average mental function.

A dose of the new improved Precursor TST provides 50% NRVs* of vitamin B6, Magnesium and Zinc. It has been proven that the combination of these three elements positively increases testosterone in people who perform intense physical activity (1). Vitamin B6 contributes to regulate hormonal activity, and magnesium and zinc play an important role in the synthesis of testosterone. Reduced production of this hormone has been attributed to a lack of Zinc (2) and magnesium has been shown to increase the presence of biologically active testosterone(1).

In addition to these minerals and vitamin B6, our Precursor TST also contains extracts of plant origin (Tribulus terrestris, Trigonella foenum-graecum, Serenoa repens, Coleus forskohlii, Passiflora incarnata y Trifolium pratense) which guarantee maximum efficiency:

The fruit of Tribulus terrestris contains saponins such as protodioscin. Studies have connected the presence of this molecule to increases in the levels of testosterone and improvement in sexual activity (3).
Among other components, Fenugreek seeds (Trigonella foenum-graecum) contain, flavonoids, alkaloids (Trigonelline), coumarin, carbohydrates and saponins. An increase in free testosterone levels and its bioavailability was observed following consumption (7).
The fruit of saw palmetto (Serenoa repens) is rich in fatty acids and has been used to treat benign hyperplasia of the prostate since some of those fatty acids inhibit the 5-alpha-reductase enzyme (10) which is implied in the metabolism of steroids.
The root of Coleus forskohlii contains forskolin, a diterpene that activates the adenylate cyclase enzyme, therefore increasing levels of cyclic AMP (12), a molecule that intervenes in different processes and raises testosterone levels when increased (13).
Passion flower (Passiflora incarnata) is a plant very well-known for its anxiolytic and relaxing properties. These properties are due to its flavonoid content, which has shown a similar effect to that of benzodiazepines (15).
Red clover (Trifolium pratense) is rich in isoflavones, molecules with an oestrogenic activity. The inhibiting effect of the aromatase enzyme has been attributed to the biochanin A isoflavone (18).

*NRVs: Nutrient Reference Value

EXTRACT NAME: Dry extract of  tribulus standardised to contain 40% in saponins
SCIENTIFIC NAME: Tribulus terrestris L.
PART USED: Fruit
PROPERTIES:
•    Contains steroidal saponins with aphrodisiac effects (3).
•    Improves erectile function (4) by increasing relaxation of the corpora cavernosa andencouraging the release of nitric oxide (5).

EXTRACT NAME: Dry extract of fenugreek standardised to contain 50% in saponins
SCIENTIFIC NAME: Trigonella foenum-graecum L.
PART USED: Seeds
PROPERTIES:
•    Increases libido (6).
•    Increases overall testosterone levels and bioavailability (7).
•    Improves strength and body composition (decreased percentage of fat) in athletes who do resistance training (8).

EXTRACT NAME: Dry extract of saw palmetto standardised to contain 20% in fatty acids
SCIENTIFIC NAME: Serenoa repens (W. Bartram) Small
PART USED: Fruit
PROPERTIES:
•    Potential use for the treatment of alopecia due to its inhibiting effect on 5-alpha reductase (9).
•    Treatment of the symptoms of benign hyperplasia of the prostate (10).

EXTRACT NAME: Dry extract of coleus standardised to contain 10% in forskolin
SCIENTIFIC NAME: Coleus forskohlii (Poir.) Briq.
PART USED: Root
PROPERTIES:
•    Forskolin, through the activation of the adenylate cyclase enzyme, stimulates the production of cyclic AMP, which promotes vasodilatation (11) and an increase in testosterone production (12-13).

NAME OF EXTRACT: Dry extract of passionflower standardised to contain 3.5% in vitexin
SCIENTIFIC NAME: Passiflora incarnata L.
PART USED: Aerial parts
PROPERTIES:
•    Anxiolytic effect (14-15)
•    Inhibition of aromatase enzyme thanks to flavonoid action (16)
•    Aphrodisiac properties (17)

NAME OF EXTRACT: Dry extract of red clover standardised to contain 8% in isoflavones
SCIENTIFIC NAME: Trifolium pratense L.
PART USED: Aerial parts
PROPERTIES:
•    The biochaninA enzyme inhibits the activity of aromatase enzyme (18).
•    Isoflavones regulate the activity of the aromatase and 5-alpha reductase enzymes (19), and influence the inhibition of cancerous cells caused by oestrogen (20).

BIBLIOGRAPHY
1. The interplay between magnesium and testosterone in modulating physical function in men. Maggio et al. (2014) Int J Endocrinol Vol 2014.
2. Molecular basis for the effects of zinc deficiency on spermatogenesis: An experimental study in the Sprague-dawley rat model. Omu et al. (2015) Indian J Urol 31(1): 57–64.
3. Aphrodisiac properties of Tribulus terrestris extract (Protodioscin) in normal and castrated rats. Gauthaman et al. Life Sci 71: 1385–1396.
4. Effects and Mechanism of Action of a Tribulus terrestris extract on penile erection. Do et al. (2013) Korean J Urol 54: 183-188.
5. Phytopharmacological overview of Tribulus terrestris. Chhatre et al. (2014) Pharmacogn Rev 8 (15): 45–51.
6. Physiological aspects of male libido enhanced by standardized Trigonella foenum-graecum extract and mineral formulation. Steels et al. (2011) Phytother Res 25(9): 1294-300.
7. Effects of glycosides based fenugreek seed extract on serum testosterone levels of healthy sedentary male subjects: an exploratory double blind, placebo controlled, crossover study. Thakurdesai et al. (2014) Asian J Pharm Clin Res Vol 7(2).
8. The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males. Poole et al. (2010)J IntSoc Sports Nutr 7: 34.
9. A Randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5ar in the treatment of androgenetic alopecia. Prager et al. (2002) J Altern Complement Med 8(2): 143-152.
10. Principles and practice of Phytotherapy. Bone and Mills (2013) Elsevier.
11. Coleus forskohlii: Alternative medicinal review. Vol 11 (1) 2006.
12. Inhibitory action of forskolin on adenylate cyclase activity and cyclic AMP generation. Khanum and Dufau (1986) J Bio Chem Vol. 261 (25): 11456-11459.
13. Body composition and forskolin consumption. Godard et al. (2005) Obesity Research 13 (8): 1335-1343.
14. Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Lakhan and Vieira (2010) Nutr J 9: 42.
15. Manual de Fitoterapia. García and Solís (2011). Elsevier
16. Passiflora incarnata Linn: A phytopharmacological review. Patel et al. (2009) Int J Green Pharm 3: 277-80.
17. Aphrodisiac activity of methanol extract of leaves of Passifloraincarnata Linn in mice. Dhawan et al. (2003) Phytother Res 17(4): 401-403.
18. The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression. Wang et al. (2008) Br J Nutr 99(2): 303-10.
19. Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones. Jarred et al. (2002) Cancer Epidemiol Biomarkers Prev 11(12): 1689-96.
20. Fitoterapia. Vademécum de prescripción. Vanaclocha and Cañigueral (2003) Elsevier.