St. John's Wort
For depression and stress
Expiration date (End Of): 12/2022 |
Lot: D14357 | Ref. SC25
3 + 1 free
Ingredients: St. John's Wort Consulting batch information
†N/A: Not applicable
Maltodextrin, anti-caking agent (E470b): magnesium salts of fatty acids. Vegetable-based capsule: hydroxypropyl methylcellulose.
This product does not contain allergens (in accordance with Regulation (EU) No 1169/2011) nor genetically modified organisms.
Description: St. John's Wort
Hypericum, or St. John's Wort, (Hypericum perforatum L.) is a plant that has been used for thousands of years to relieve nervous system disorders and is currently the most widely used herbal medicine for mild to moderate depression.
Numerous studies support the use of hypericum for mild to moderate depressive episodes. It also has fewer side effects than synthetic antidepressants.
Its flowering tops contain hypericin and flavonoids, compounds with pharmacological activity that contribute to hypericum’s antidepressant effect.
Our hypericum extract is standardised to contain 0,3% hypericin, guaranteeing maximum efficacy.
St. John's Wort: Detailed information
Hypericum: Description and origin
Hypericum, or St. John’s Wort, (Hypericum perforatum L.) is a perennial herbaceous plant that belongs to the hypericaceae family. Its leaves contain multiple glands visible against the light and its flowers have five golden yellow petals with numerous prominent stamen (1) that appear from May to August. It can grow up to one metre tall and mainly branches from the top of the stem; it has a woody, highly branched and fusiform root (2).
Hypericum is native to temperate regions of Europe. It can be found in almost all European countries, as far as eastern Russia, and has acclimatised in many parts of the world, such as China, Australia, North Africa and America (2).
Hypericum has been used for thousands of years: Hippocrates used this plant as an anti-inflammatory; Dioscorides cited it in his encyclopaedia on medicinal plants and remedies, as did Galen and Pliny in their works (3).
The name hypericum comes from the Greek hyperikon (“over images; over an apparition”), which, according to some, refers to hypericum’s ability to expel evil spirits; while for others the glands of its petals appeared to form images. Perforatum, meanwhile, refers to the fact that if the plant is observed against the light it has a perforated appearance due to the oil glands present in its leaves and sepals (2).
In the Middle Ages it was believed that the scent of hypericum drove away evil spirits, and it was hung from roofs to prevent lightning and fire. It was also believed that to obtain these magical properties, it should be harvested in the early morning on St. John’s Day (24 June), the date on which St. John the Baptist was beheaded, which also coincides with the plant’s flowering (3).
The flowering tops* of hypericum contain essential oil, coumarins (umbelliferone), phytosterols (beta-sitosterol), flavonoids, naphthodianthrones (hypericin, pseudohypericin, isohypericin and protohypericin) and prenylated phloroglucinol derivatives (hyperforin and adhyperforin). According to French Pharmacopoeia and Deutscher Arzneimittel-Codex, the extract must contain at least 0.04% of naphthodianthrones calculated as hypericin (4).
*Flowering top: the top of a plant when in flower.
Hypericum is recommended mainly for mild and moderate depressive episodes, anxiety, night terrors, neurovegetative disorders associated with the menopause (hot flushes, night sweats etc.) and sleep disorders (1,4-5).
Hypericum is often used to relieve the symptoms of mild to moderate depression, since the side effects are fewer than those of synthetic antidepressants, and hypericum, or St. John’s Wort, is one of the most widely used plants. In Germany, for example, prescriptions of hypericum account for 25% all antidepressant prescriptions (6).
Multiple studies support the use of hypericum for mild to moderate depression. A review evaluating 29 clinical trials concluded that the effect of hypericum was greater than that of the placebo, and similar to synthetic antidepressants. It was also found that the side effects of hypericum were fewer than those of synthetic antidepressants (7).
Depression is associated with decreased levels of the neurotransmitters serotonin, dopamine and norepinephrine (6). The antidepressant effect of hypericum is due to several mechanisms of action (1,6). For example, hypericum extract inhibits the monoamine oxidase (MAO-A and MAO-B) enzymes, which degrade serotonin and norepinephrine. It also inhibits the reuptake of neurotransmitters involved in depression (serotonin, dopamine, norepinephrine etc.). Both mechanisms promote increased availability of neurotransmitters.
Finally, hypericum extract is also used to relieve anxiety and sleep disorders (8). In vitro studies indicate that hypericum compounds may interact with receptors that mediate anxiolytic effects, such as GABA receptors (1).
- Bone K, Mills S. Principles and Practice of Phytotherapy: Modern Herbal Medicine. 2nd Edition. Edinburgh/New York. Churchill Livingstone/Elsevier. 2013.
- Berdonces i Serra JL. Gran Enciclopedia de las plantas medicinales. Madrid: Tikal Ediciones, 2002.
- Peiró et al. (2010) Monográfico de Hypericum perforatum L. Medicina Naturista 4 (2): 57-62.
- Vanaclocha B, Cañigueral S (Eds). Fitoterapia. Vademécum de prescripción. 4ª Edición. Barcelona: Elsevier Masson, 2003.
- EMA-HMPC. Community herbal monograph on Hypericum perforatum L., herba (well-established medicinal use). London: EMA. Doc. Ref.: EMA/HMPC/101304/2008. Adopted: 12-11-2009.
- Castillo-García E, Martínez-Solís I. Manual de Fitoterapia. 1ª Edición revisada. España: Elsevier Masson, 2011.
- Linde et al. (2008) St John's wort for major depression. Cochrane Database Syst Rev 8(4): CD000448.
- Lakhan and Vieira (2010) Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Nutrition J 9: 42.
Use: St. John's Wort Consulting batch information
1 capsule per day with half a glass of water at mealtime.
Inform your doctor or pharmacist if simultaneously taking medication. Not recommended for pregnant or lactating women. Do not exceed the recommended daily dose.
Does not replace a varied and balanced diet and a healthy lifestyle. For adult use only. Keep out of reach of young children.
Store in a cool dry place away from sunlight.
Quality: St. John's Wort Consulting batch information
PRODUCT NAMESt. John's Wort
BOTANICAL NAMEHypericum perforatum L.
SERVINGS PER CONTAINER60 servings
FABRICATION AND GUARANTEE:
This dietary supplement is manufactured by a GMP-compliant laboratory (GMPs are the Good Manufacturing Practice guidelines for the European pharmaceutical industry).
Their active principle content is guaranteed through regular tests.
The labelling of our products complies with Regulation (EU) No 1169/2011 of the European Parliament and of the Council of 25 October 2011 and its subsequent amendments, with the aim of ensuring a high level of consumer protection in relation to food information.
Our packaging complies with Regulation (EC) No 1935/2004 of the European Parliament and of the Council of 27 October 2004 and its subsequent amendments on materials and articles intended to come into contact with food, aiming to secure a high level of protection of human health and the interests of consumers.
Anastore is registered on the Food Safety Register of Food Business Operators, whose purpose is to protect public health and consumer interests, where the definitions provided for in Articles 2 and 3 of Regulation (EC) No 178/2002 and Article 2 of Regulation (EC) No 852/2004 of the European Parliament and of the Council, and their subsequent amendments, are applicable.
These Regulations lay down the general principles and requirements of food law, establishing the European Food Safety Authority and laying down procedures in matters of food safety, in addition to laying down general rules in relation to the hygiene of foodstuffs.
Finally, Anastore notifies the placing on the market of its food supplements in accordance with the specific regulations of each country.
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Certificate issue date: 2020/12/31