St. John's Wort

Standardised extract

Effective treatment for depression and stress

St. John's Wort

PRINCIPAL INDICATIONS:

Depression, mood swings, anxiety

14,50 €

Ref. SC25 In Stock

Health claims accepted by the following organisations:

The Commission E recognise St. John’s Wortas a treatment for psychosomatic disorders, depression, anxiety and nervous agitation, while the WHO recognises it as a herbal treatment for mild to moderate depression. The Commission E also recognises St. John’s Wort oil as an effective treatment for digestive problems (dyspepsia).

Description

Hypericum, or St. John's Wort, (Hypericum perforatum L.) is a plant that has been used for thousands of years to relieve nervous system disorders and is currently the most widely used herbal medicine for the treatment of mild to moderate depression.

Numerous studies support the use of hypericum to treat mild to moderate depressive episodes. It also has fewer side effects than synthetic antidepressants.

Its flowering tops contain hypericin and flavonoids, compounds with pharmacological activity that contribute to hypericum’s antidepressant effect.

Our hypericum extract is standardised to contain 0,3% hypericin, guaranteeing maximum efficacy.


Detailed information

Hypericum: Description and origin

Hypericum, or St. John’s Wort, (Hypericum perforatum L.) is a perennial herbaceous plant that belongs to the hypericaceae family. Its leaves contain multiple glands visible against the light and its flowers have five golden yellow petals with numerous prominent stamen (1) that appear from May to August. It can grow up to one metre tall and mainly branches from the top of the stem; it has a woody, highly branched and fusiform root (2).

Hypericum is native to temperate regions of Europe. It can be found in almost all European countries, as far as eastern Russia, and has acclimatised in many parts of the world, such as China, Australia, North Africa and America (2).

Hypericum: History

Hypericum has been used for thousands of years, due to its medicinal properties: Hippocrates used this plant as an anti-inflammatory remedy; Dioscorides cited it in his encyclopaedia on medicinal plants and remedies, as did Galen and Pliny in their works (3).

The name hypericum comes from the Greek hyperikon (“over images; over an apparition”), which, according to some, refers to hypericum’s ability to expel evil spirits; while for others the glands of its petals appeared to form images. Perforatum, meanwhile, refers to the fact that if the plant is observed against the light it has a perforated appearance due to the oil glands present in its leaves and sepals (2).

In the Middle Ages it was believed that the scent of hypericum drove away evil spirits, and it was hung from roofs to prevent lightning and fire. It was also believed that to obtain these magical properties, it should be harvested in the early morning on St. John’s Day (24 June), the date on which St. John the Baptist was beheaded, which also coincides with the plant’s flowering (3).

Hypericum: Composition

The flowering tops* of hypericum contain essential oil, coumarins (umbelliferone), phytosterols (beta-sitosterol), flavonoids, naphthodianthrones (hypericin, pseudohypericin, isohypericin and protohypericin) and prenylated phloroglucinol derivatives (hyperforin and adhyperforin). According to French Pharmacopoeia and Deutscher Arzneimittel-Codex, the extract must contain at least 0.04% of naphthodianthrones calculated as hypericin (4).

*Flowering top: the top of a plant when in flower.

Hypericum: Our extract

Extract name: Dry extract of hypericum

Scientific name: Hypericum perforatum L.

Part used: Flowering tops

Hypericum: Benefits

Hypericum is recommended mainly for the treatment of mild and moderate depressive episodes, anxiety, night terrors, neurovegetative disorders associated with the menopause (hot flushes, night sweats etc.) and sleep disorders (1,4-5).

Hypericum: Usage, dosage

One dose of our product contains 230 mg dry extract of flowering tops of hypericum, standardised to contain 0.3% hypericin (i.e. 690 𝜇g).

Hypericum: Studies/research

The European Medicines Agency (EMA) has approved the use of hypericum for the treatment of mild and moderate depressive episodes (5).

Herbal medicine is often used to relieve the symptoms of mild to moderate depression, since the side effects are fewer than those of synthetic antidepressants, and hypericum, or St. John’s Wort, is one of the most widely used plants. In Germany, for example, prescriptions of hypericum account for 25% all antidepressant prescriptions (6).

Multiple studies support the use of hypericum for the treatment of mild to moderate depression. A review evaluating 29 clinical trials concluded that the effect of hypericum was greater than that of the placebo, and similar to synthetic antidepressants. It was also found that the side effects of hypericum were fewer than those of synthetic antidepressants (7).

Depression is associated with decreased levels of the neurotransmitters serotonin, dopamine and norepinephrine (6). The antidepressant effect of hypericum is due to several mechanisms of action (1,6). For example, hypericum extract inhibits the monoamine oxidase (MAO-A and MAO-B) enzymes, which degrade serotonin and norepinephrine. It also inhibits the reuptake of neurotransmitters involved in depression (serotonin, dopamine, norepinephrine etc.). Both mechanisms promote increased availability of neurotransmitters.

Finally, hypericum extract is also used to relieve anxiety and sleep disorders (8). In vitro studies indicate that hypericum compounds may interact with receptors that mediate anxiolytic effects, such as GABA receptors (1).

Hypericum: Bibliography

1. Bone K, Mills S. Principles and Practice of Phytotherapy: Modern Herbal Medicine. 2nd Edition. Edinburgh/New York. Churchill Livingstone/Elsevier. 2013.

2. Berdonces i Serra JL. Gran Enciclopedia de las plantas medicinales [encyclopedia of medicinal plants]. Madrid: Tikal Ediciones, 2002.

3. Peiró et al. (2010) Monográfico de Hypericum perforatum [monograph on Hypericum perforatum L.] L. Medicina Naturista 4 (2) : 57-62.

4. Vanaclocha B, Cañigueral S (Eds). Fitoterapia. Vademécum de prescripción. [Phytotherapy. Prescription handbook] 4ª Edición. Barcelona: Elsevier Masson, 2003.

5. EMA-HMPC. Community herbal monograph on Hypericum perforatum L., herba (well-established medicinal use). London: EMA. Doc. Ref.: EMA/HMPC/101304/2008. Adopted: 12-11-2009.

6. Castillo-García E, Martínez-Solís I. Manual de Fitoterapia [Herbal medicine manual]. 1ª Edición revisada. España: Elsevier Masson, 2011.

7. Linde et al. (2008) St John's wort for major depression. Cochrane Database Syst Rev 8(4): CD000448.

8. Lakhan and Vieira (2010) Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Nutrition J 9: 42.

Composition

INGREDIENTS:

Each capsule contains: 230 mg St. John's Wort flower dry extract (Hypericum perforatum L.), standardised to contain 0.3% hypericin (690 µg).

OTHER INGREDIENTS:

maltodextrin, anti-caking agent (E470b): magnesium stearate, vegetable-based capsule: hydroxypropyl methylcellulose.

ALLERGENS:

This product does not contain allergens (in accordance with Regulation (EU) No 1169/2011) nor genetically modified organisms.

FABRICATION AND GUARANTEE:

This dietary supplement is manufactured by a GMP-compliant laboratory (GMPs are the good manufacturing practice guidelines for the European pharmaceutical industry).
Their active principle content is guaranteed through regular tests, which can be viewed online.

Use

DIRECTIONS:

1 capsule per day with half a glass of water at mealtime.

WARNINGS:

Inform your doctor or pharmacist if you are taking other medication at the same time. Not recommended for pregnant or lactating women. Do not exceed the recommended daily dose.

ADVICES:

Does not replace a varied and balanced diet and a healthy lifestyle. If you are undergoing medical treatment, seek your therapist's advice. For adult use only. Keep out of reach of young children.

STORAGE INSTRUCTIONS:

Store in a cool dry place away from sunlight.

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