St. John's Wort

Effective treatment for depression and stress

Standardised extract

14,50 €

St. John's Wort
Made in France | Expiration date (End Of): 03/2022
Lot: D13730 |
Ref. SC25

1 unit

3 + 1 free

Description: St. John's Wort

Health claims

The Commission E recognise St. John’s Wortas a treatment for psychosomatic disorders, depression, anxiety and nervous agitation, while the WHO recognises it as a herbal treatment for mild to moderate depression. The Commission E also recognises St. John’s Wort oil as an effective treatment for digestive problems (dyspepsia).

Hypericum, or St. John's Wort, (Hypericum perforatum L.) is a plant that has been used for thousands of years to relieve nervous system disorders and is currently the most widely used herbal medicine for mild to moderate depression.

Numerous studies support the use of hypericum for mild to moderate depressive episodes. It also has fewer side effects than synthetic antidepressants.

Its flowering tops contain hypericin and flavonoids, compounds with pharmacological activity that contribute to hypericum’s antidepressant effect.

Our hypericum extract is standardised to contain 0,3% hypericin, guaranteeing maximum efficacy.

Detailed information

Hypericum: Description and origin

Hypericum, or St. John’s Wort, (Hypericum perforatum L.) is a perennial herbaceous plant that belongs to the hypericaceae family. Its leaves contain multiple glands visible against the light and its flowers have five golden yellow petals with numerous prominent stamen (1) that appear from May to August. It can grow up to one metre tall and mainly branches from the top of the stem; it has a woody, highly branched and fusiform root (2).

Hypericum is native to temperate regions of Europe. It can be found in almost all European countries, as far as eastern Russia, and has acclimatised in many parts of the world, such as China, Australia, North Africa and America (2).

Hypericum: History

Hypericum has been used for thousands of years, due to its medicinal properties: Hippocrates used this plant as an anti-inflammatory remedy; Dioscorides cited it in his encyclopaedia on medicinal plants and remedies, as did Galen and Pliny in their works (3).

The name hypericum comes from the Greek hyperikon (“over images; over an apparition”), which, according to some, refers to hypericum’s ability to expel evil spirits; while for others the glands of its petals appeared to form images. Perforatum, meanwhile, refers to the fact that if the plant is observed against the light it has a perforated appearance due to the oil glands present in its leaves and sepals (2).

In the Middle Ages it was believed that the scent of hypericum drove away evil spirits, and it was hung from roofs to prevent lightning and fire. It was also believed that to obtain these magical properties, it should be harvested in the early morning on St. John’s Day (24 June), the date on which St. John the Baptist was beheaded, which also coincides with the plant’s flowering (3).

Hypericum: Composition

The flowering tops* of hypericum contain essential oil, coumarins (umbelliferone), phytosterols (beta-sitosterol), flavonoids, naphthodianthrones (hypericin, pseudohypericin, isohypericin and protohypericin) and prenylated phloroglucinol derivatives (hyperforin and adhyperforin). According to French Pharmacopoeia and Deutscher Arzneimittel-Codex, the extract must contain at least 0.04% of naphthodianthrones calculated as hypericin (4).

*Flowering top: the top of a plant when in flower.

Hypericum: Benefits

Hypericum is recommended mainly for mild and moderate depressive episodes, anxiety, night terrors, neurovegetative disorders associated with the menopause (hot flushes, night sweats etc.) and sleep disorders (1,4-5).

Hypericum: Studies/research

The European Medicines Agency (EMA) has approved the use of hypericum for mild and moderate depressive episodes (5).

Herbal medicine is often used to relieve the symptoms of mild to moderate depression, since the side effects are fewer than those of synthetic antidepressants, and hypericum, or St. John’s Wort, is one of the most widely used plants. In Germany, for example, prescriptions of hypericum account for 25% all antidepressant prescriptions (6).

Multiple studies support the use of hypericum for mild to moderate depression. A review evaluating 29 clinical trials concluded that the effect of hypericum was greater than that of the placebo, and similar to synthetic antidepressants. It was also found that the side effects of hypericum were fewer than those of synthetic antidepressants (7).

Depression is associated with decreased levels of the neurotransmitters serotonin, dopamine and norepinephrine (6). The antidepressant effect of hypericum is due to several mechanisms of action (1,6). For example, hypericum extract inhibits the monoamine oxidase (MAO-A and MAO-B) enzymes, which degrade serotonin and norepinephrine. It also inhibits the reuptake of neurotransmitters involved in depression (serotonin, dopamine, norepinephrine etc.). Both mechanisms promote increased availability of neurotransmitters.

Finally, hypericum extract is also used to relieve anxiety and sleep disorders (8). In vitro studies indicate that hypericum compounds may interact with receptors that mediate anxiolytic effects, such as GABA receptors (1).

Bibliography

  1. Bone K, Mills S. Principles and Practice of Phytotherapy: Modern Herbal Medicine. 2nd Edition. Edinburgh/New York. Churchill Livingstone/Elsevier. 2013.
  2. Berdonces i Serra JL. Gran Enciclopedia de las plantas medicinales. Madrid: Tikal Ediciones, 2002.
  3. Peiró et al. (2010) Monográfico de Hypericum perforatum L. Medicina Naturista 4 (2): 57-62.
  4. Vanaclocha B, Cañigueral S (Eds). Fitoterapia. Vademécum de prescripción. 4ª Edición. Barcelona: Elsevier Masson, 2003.
  5. EMA-HMPC. Community herbal monograph on Hypericum perforatum L., herba (well-established medicinal use). London: EMA. Doc. Ref.: EMA/HMPC/101304/2008. Adopted: 12-11-2009.
  6. Castillo-García E, Martínez-Solís I. Manual de Fitoterapia. 1ª Edición revisada. España: Elsevier Masson, 2011.
  7. Linde et al. (2008) St John's wort for major depression. Cochrane Database Syst Rev 8(4): CD000448.
  8. Lakhan and Vieira (2010) Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Nutrition J 9: 42.
Updated on 2019/05/30
Serving size: 1 capsule
Servings per container: 60
INGREDIENTS:
Amount per serving
NRVs*
Dry extract of St. John's Wort flower (Hypericum perforatum L.)
230.00 mg
N/A†
Hypericin (0.3%)
0.69 mg
N/A†
*NRVs: Nutrient Reference Values
†N/A: Not applicable

Other ingredients:

Maltodextrin, anti-caking agent (E470b): magnesium salts of fatty acids. Vegetable-based capsule: hydroxypropyl methylcellulose.

Food allergens:

This product does not contain allergens (in accordance with Regulation (EU) No 1169/2011) nor genetically modified organisms.

Updated on 2020/05/12

DIRECTIONS:

1 capsule per day with half a glass of water at mealtime.

WARNINGS:

Inform your doctor or pharmacist if you are taking other medication at the same time. Not recommended for pregnant or lactating women. Do not exceed the recommended daily dose.

ADVICES:

Does not replace a varied and balanced diet and a healthy lifestyle. For adult use only. Keep out of reach of young children.

STORAGE INSTRUCTIONS:

Store in a cool dry place away from sunlight.

Updated on 2020/05/12

PRODUCT NAME

St. John's Wort

BOTANICAL NAME

Hypericum perforatum L.

REFERENCE

SC25

QUANTITY

60 capsules

BATCH NUMBER

D13730

EXPIRATION DATE

2022/03

MADE

In France

SERVINGS PER CONTAINER

60 servings

FABRICATION AND GUARANTEE:

This dietary supplement is manufactured by a GMP-compliant laboratory (GMPs are the Good Manufacturing Practice guidelines for the European pharmaceutical industry).

Their active principle content is guaranteed through regular tests, which can be viewed online.

The labelling of our products complies with Regulation (EU) No 1169/2011 of the European Parliament and of the Council of 25 October 2011 and its subsequent amendments, with the aim of ensuring a high level of consumer protection in relation to food information.

Our packaging complies with Regulation (EC) No 1935/2004 of the European Parliament and of the Council of 27 October 2004 and its subsequent amendments on materials and articles intended to come into contact with food, aiming to secure a high level of protection of human health and the interests of consumers.

CHARACTERISTICS:

VEGETABLE CAPSULES

NOT IRRADIATED

WITHOUT ALLERGENS

WITHOUT BPA

NO OMG

WITHOUT LACTOSE

VEGAN

PRODUCT ANALYSIS:

ORGANOLEPTIC QUALITY

SPECIFICATIONS

RESULTS

Appearance:
Powder
Conform with specifications
Colour:
Dark brown
Conform with specifications
Odour:
Characteristic
Conform with specifications

ANALYTICAL QUALITY

SPECIFICATIONS

RESULTS

Irradiation detection:
Not irradiated
Conform with specifications

MICROBIOLOGICAL QUALITY

SPECIFICATIONS

RESULTS

Plate count:
NMT 10000 cfu/g
Conform with European Pharmacopoeia 8.0
Yeasts and molds:
NMT 100 cfu/g
Conform with European Pharmacopoeia 8.0
E. coli:
Negative
Conform with European Pharmacopoeia 8.0
Salmonella:
Negative
Conform with European Pharmacopoeia 8.0
Enterobacteraceae:
NMT 100 cfu/g
Conform with European Pharmacopoeia 8.0

PRODUCT REGISTRATION:

Anastore is registered on the Food Safety Register of Food Business Operators, whose purpose is to protect public health and consumer interests, where the definitions provided for in Articles 2 and 3 of Regulation (EC) No 178/2002 and Article 2 of Regulation (EC) No 852/2004 of the European Parliament and of the Council, and their subsequent amendments, are applicable.

These Regulations lay down the general principles and requirements of food law, establishing the European Food Safety Authority and laying down procedures in matters of food safety, in addition to laying down general rules in relation to the hygiene of foodstuffs.

Finally, Anastore notifies the placing on the market of its food supplements in accordance with the specific regulations of each country.

Registration QR Code


Registration declaration

HEAD OF THE QUALITY DEPARTMENT

Certificate issue date: 2020/05/13

Updated on 2020/05/12

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