St. John's Wort
For depression and stress
Expiration date (End Of): 08/2023 |
Lot: D15106 | Ref. SC25
3 + 1 free
Ingredients: St. John's Wort Consulting batch information
†N/A: Not applicable
Maltodextrin, anti-caking agent (E470b): magnesium salts of fatty acids. Vegetable-based capsule: hydroxypropyl methylcellulose.
This product does not contain allergens (in accordance with Regulation (EU) No 1169/2011) nor genetically modified organisms.
Description: St. John's Wort
Hypericum, or St. John's Wort, (Hypericum perforatum L.) is a plant that has been used for thousands of years to relieve nervous system disorders and is currently the most widely used plant for mild to moderate depression.
Numerous studies support the use of hypericum for mild to moderate depressive episodes. It also has fewer side effects than synthetic antidepressants.
Its flowering tops contain hypericin and flavonoids, compounds with pharmacological activity that contribute to hypericum’s antidepressant effect.
Our hypericum extract is standardised to contain 0,3% hypericin, guaranteeing maximum efficacy.
St. John's Wort: Detailed information
Hypericum: Description and origin
Hypericum, or St. John’s Wort, (Hypericum perforatum L.) is a perennial herbaceous plant that belongs to the hypericaceae family. Its leaves contain multiple glands visible against the light and its flowers have five golden yellow petals with numerous prominent stamen1 that appear from May to August. It can grow up to one metre tall and mainly branches from the top of the stem; it has a woody, highly branched and fusiform root2.
Hypericum is native to temperate regions of Europe. It can be found in almost all European countries, as far as eastern Russia, and has acclimatised in many parts of the world, such as China, Australia, North Africa and America2.
Hypericum has been used for thousands of years: Hippocrates used this plant as an anti-inflammatory; Dioscorides cited it in his encyclopaedia, as did Galen and Pliny in their works3.
The name hypericum comes from the Greek hyperikon (“over images; over an apparition”), which, according to some, refers to hypericum’s ability to expel evil spirits; while for others the glands of its petals appeared to form images. Perforatum, meanwhile, refers to the fact that if the plant is observed against the light it has a perforated appearance due to the oil glands present in its leaves and sepals2.
In the Middle Ages it was believed that the scent of hypericum drove away evil spirits, and it was hung from roofs to prevent lightning and fire. It was also believed that to obtain these magical properties, it should be harvested in the early morning on St. John’s Day (24 June), the date on which St. John the Baptist was beheaded, which also coincides with the plant’s flowering3.
The flowering tops* of hypericum contain essential oil, coumarins (umbelliferone), phytosterols (beta-sitosterol), flavonoids, naphthodianthrones (hypericin, pseudohypericin, isohypericin and protohypericin) and prenylated phloroglucinol derivatives (hyperforin and adhyperforin). According to French Pharmacopoeia and Deutscher Arzneimittel-Codex, the extract must contain at least 0.04% of naphthodianthrones calculated as hypericin4.
*Flowering top: the top of a plant when in flower.
Hypericum is recommended mainly for mild and moderate depressive episodes, anxiety, night terrors, neurovegetative disorders associated with the menopause (hot flushes, night sweats etc.) and sleep disorders1, 4 ,5.
Hypericum is often used to relieve the symptoms of mild to moderate depression, since the side effects are fewer than those of synthetic antidepressants, and hypericum, or St. John’s Wort, is one of the most widely used plants. In Germany, for example, prescriptions of hypericum account for 25% all antidepressant prescriptions6.
Multiple studies support the use of hypericum for mild to moderate depression. A review evaluating 29 clinical trials concluded that the effect of hypericum was greater than that of the placebo, and similar to synthetic antidepressants. It was also found that the side effects of hypericum were fewer than those of synthetic antidepressants7.
Depression is associated with decreased levels of the neurotransmitters serotonin, dopamine and norepinephrine6. The antidepressant effect of hypericum is due to several mechanisms of action1, 6. For example, hypericum extract inhibits the monoamine oxidase (MAO-A and MAO-B) enzymes, which degrade serotonin and norepinephrine. It also inhibits the reuptake of neurotransmitters involved in depression (serotonin, dopamine, norepinephrine etc.). Both mechanisms promote increased availability of neurotransmitters.
Finally, hypericum extract is also used to relieve anxiety and sleep disorders8. In vitro studies indicate that hypericum compounds may interact with receptors that mediate anxiolytic effects, such as GABA receptors1.
- Principles and Practice of Phytotherapy: Modern Herbal Medicine. Bone K, Mills S. 2nd Edition. Edinburgh/New York. Churchill Livingstone/Elsevier. 2013.
- Gran Enciclopedia de las plantas medicinales. Berdonces i Serra JL. Madrid: Tikal Ediciones, 2002.
- Monográfico de Hypericum perforatum L. Peiró et al. Medicina Naturista. 2010. 4 (2): 57-62.
- Fitoterapia. Vademécum de prescripción. Vanaclocha B, Cañigueral S (Eds). 4ª Edición. Barcelona: Elsevier Masson, 2003.
- EMA-HMPC. Community herbal monograph on Hypericum perforatum L., herba (well-established medicinal use). London: EMA. Doc. Ref.: EMA/HMPC/101304/2008. Adopted: 12-11-2009.
- Manual de Fitoterapia. Castillo-García E, Martínez-Solís I. 1ª Edición revisada. España: Elsevier Masson, 2011.
- St John's wort for major depression. Linde et al. Cochrane Database Syst Rev. 2008. 8(4): CD000448.
- Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Lakhan and Vieira. Nutr J. 2010 9: 42.
Use: St. John's Wort Consulting batch information
1 capsule per day with half a glass of water at mealtime.
Inform your doctor or pharmacist if simultaneously taking medication. Not recommended for pregnant or lactating women. Do not exceed the recommended daily dose.
Does not replace a varied and balanced diet and a healthy lifestyle. For adult use only. Keep out of reach of young children.
Store in a cool dry place away from sunlight.
Quality: St. John's Wort Consulting batch information
PRODUCT NAMESt. John's Wort
BOTANICAL NAMEHypericum perforatum L.
SERVINGS PER CONTAINER60 servings
FABRICATION AND GUARANTEE:
This dietary supplement is manufactured by a GMP-compliant laboratory (GMPs are the Good Manufacturing Practice guidelines for the European pharmaceutical industry).
The active principle content is guaranteed through regular tests.
HEAD OF THE QUALITY DEPARTMENT
Certificate issue date: 2021/09/09