Joint pain

The most effective natural compounds for combating joint pain

Harpagophytum, Turmeric, Uncaria Tomentosa

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Joint pain
The most effective natural compounds for combating joint pain
Made in France | Expiration date (End Of): 05/2023
Lot: D14765 |
Ref. SC65

1 unit

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Ingredients: Joint pain
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Serving size: 2 capsules
Servings per container: 30
INGREDIENTS:
Amount per serving
NRVs*
Dry extract of devil's claw root (Harpagophytum procumbens (Burch.) DC.)
400.00 mg
N/A†
Harpagosides (2.7%)
10.80 mg
N/A†
Dry extract of turmeric rhizome (Curcuma longa L.)
200.00 mg
N/A†
Curcuminoids (95%)
190.00 mg
N/A†
Dry extract of cat’s claw bark (Uncaria tomentosa (Willd. ex Schult.) DC.)
20.00 mg
N/A†
Alkaloids (3%)
0.60 mg
N/A†
*NRVs: Nutrient Reference Values
†N/A: Not applicable

Other ingredients:

Potato starch. Vegetable-based capsule: hydroxypropyl methylcellulose.

Food allergens:

This product does not contain allergens (in accordance with Regulation (EU) No 1169/2011) nor genetically modified organisms.

Updated on 2021/05/31

Description: Joint pain

A blend of 3 natural components renowned for their effectiveness in joint pain.

  • Dry extract of Harpagophytum (Devil’s Claw) root, with standardised Harpagoside content:
    Our patented Devil's claw extract with standardised harpagoside content inhibits COX-2, the enzyme involved in the inflammation process and reduces pains and stiffness. Clinical studies indicate that it is particularly effective in relieving back pain.
  • Dry extract of Turmeric rhizome with standardised curcuminoid content:
    The antioxidant properties of curcumin present in the rhizome Curcuminoid root extract boosts the effect of the harpagophytum. It protects our bodies against inflammation and regulates the action of the enzymes responsible for avoid cartilage deterioration.
    Dry extract of Uncaria Tomentosa (Cat’s claw) bark with standardised Alkaloid content:
  • The primary action of the alkaloids present in this bark is stimulating the immune system. This action allows the body to fight against autoimmune diseases that attack healthy tissue in cartilage by mistake, bone fractures, viral and bacterial infections and the effects of ageing, 4 key factors in arthritis.

 

Detailed information

Conditions such as arthritis and back and joint pain due to inflammation or cartilage deterioration are becoming more and more common. If our bones are fragile, we run the risk of fractures, sprains and musculoskeletal illness.

Maintaining a balanced diet and physical exercise are essential to avoid this type of condition. This helps to avoid weakening the immune system, which can cause the tissue damage that allows these illnesses to develop.

Pharmacological treatment of joint problems focuses on three lines of therapy. The first is treatment with nonsteroidal anti-inflammatory drugs (NSAIDS), which reduce inflammation; the second with immunosuppressants to avoid outbreaks or relapses; and the third with selective inhibitors of tumor necrosis factors (TNF), which bring about a reduction in inflammation and pain.

Extracts of harpagophytum, turmeric and cat’s claw have analgesic and anti-inflammatory effects, promote cartilage regeneration and reduce pain. This offers a natural yet effective alternative to the treatment of common joint problems.

EXTRACTS’ PROPERTIES:

 

COMMON NAME: Devil’s claw
Part used: Root
SCIENTIFIC NAME: Harpagophytum procumbens (Burch) DC.
ACTIVE SUBSTANCE: 2.5% Harpagosides

PROPERTIES:

  • Harpagosides have anti-inflammatory and analgesic properties, due to their inhibitory action on the cyclooxygenase-2 (COX-2) and nitric oxide synthase (NOS) enzymes1.
  • Promotes cartilage regeneration, increasing the elasticity and number of collagen fibres2.
  • Acts as an antibacterial agent against aerobic, anaerobic bacteria and yeasts3.
  • Several double blind studies on humans, where a placebo group is tested against a control group, indicate a significant reduction in back pain4.

OUR EXTRACT:

Harpagophytum procumbens is a plant native to southern Africa, traditionally used by the indigenous people of the Kalahari Desert for its analgesic and anti-inflammatory properties. It can also be used in case of joint pain.

In our devil's claw extract, standardised to contain 2.5% harpagosides, only the secondary roots of the harpagophytum, which contain a higher concentration of harpagosides than the primary roots, are used. The harpagophytum extract acts as an anti-inflammatory, reducing pain. In studies conducted on this extract it has been shown to inhibit COX-2 and regenerate the extracellular matrix through the formation of glycosaminoglycans, and to stimulate the synthesis of hyaluronic acid, which acts as a lubricant in the joints during slow movements and absorbs elastic shock during rapid movements.

 

COMMON NAME: Turmeric
Part used: Rhizome
SCIENTIFIC NAME: Curcuma longa L.
ACTIVE SUBSTANCE: 95% Curcuminoids

PROPERTIES:

  • Turmeric has anti-inflammatory effects, through the modulation of eicosanoid metabolism. It also has immunomodulatory capacity, primarily by altering the profile of the Thl cytokines of the helper or auxiliary T-cells5.
  • Curcuminoids are known for their antioxidant action, avoiding the formation of free radicals that cause cell degeneration.
  • Triggers the release of mediators of inflammation that activate cartilage repair (cytokines such as TNFα, IL-1, IL-6), through the chondrocytes that stop the reaction cascades that fuel the degeneration of the cartilage matrix6-8.

OUR EXTRACT:

Turmeric is a spice native to Southeast Asia that has a distinctive aroma and intense orange-yellow colour.  It is a plant widely studied for its curcuminoids, which are credited with numerous properties.

Our turmeric extract is standardised to contain 95% curcuminoids, which are the molecules responsible for its antioxidant, anti-inflammatory, cartilage repair and immunomodulatory properties.

 

COMMON NAME: Cat’s claw
Part used: Bark
SCIENTIFIC NAME: Uncaria tomentosa (Wild) D.C
ACTIVE SUBSTANCE: 3% Alkaloids

PROPERTIES:

  • The alkaloids in our cat’s claw extract reduce pain in case of rheumatoid arthritis9.
  • Stimulates the immune system – alkaloids promote phagocytosis (ability of white blood cells to attack and destroy foreign cells)10.
  • The anti-inflammatory action stems from its cytokine-inhibiting ability, and from TNF alpha, crucial mediators in immune response11.
  • In vitro studies have observed antimicrobial activity against Enterobacteriaceae, S. mutans and Staphylococcus spp12.

OUR EXTRACT:

Cat’s claw is a plant native to Peru, whose alkaloid-rich bark has been used for over two thousand years as an immunostimulant and anti-inflammatory tonic.

Our cat’s claw bark extract is standardised to contain 3% alkaloids, molecules that have been studied for their immunostimulatory and antiviral action, and their ability to reduce joint pain. 

Bibliography

  1. Harpagophytum procumbens Suppresses Lipopolysaccharide-Stimulated Expressions of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Fibroblast Cell Line L929. Mi-Hyeon Jang, Sabina Lim, Seung-Moo Han et al. J. of Pharmacological Sciences. 2003. 93(3): 367-71.
  2. Principes and practice of phytoteraphy. Tam LS, Chan TYK, Leung WK, et al. Aust NZ. J Med. 2013.
  3. Principes and practice of phytoteraphy. Devi PU. Indian J Exp Biol. 2013.
  4. Principes and practice of phytoteraphy. Singh N, Singh SP, Nath R, et al. Inst J Crude Drug Res. 2013.
  5. Pharmacological and nutritional effects of Curcuma longa L. extracts and curcuminoids. Mesa, M.D. Ars Pharm. 2001. 41 (3): 307-321.
  6. Modulation of inflammatory mediators by Ibuprofen and Curcumin treatment during chronic inflammation in rat. Banerjee, et al. Immunopharmacol Immunotoxicol. 2003, 25(2): 213-224.
  7. Differential regulation of cytokines and transcription factors in liver by curcumin following hemorrhage/resuscitation. Gaddipati, et al. Shock. 2003. 19 (2): 150-156.
  8. The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa B. Bierhous, et al.Thromb Haematost. 1997, 77(4): 772-782.
  9. Randomized doublé bilind trial of an extract from the pentacyclic alcaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis. Erich Mur, et al. J of Rheumatology. 2002. 29(4): 678-81.
  10. Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel asqueous extract from Uncaria tomentosa. Yezhou Sheng, et al. J Ethnopharmacol. 2000. 69(2): 115-26.
  11. Tretament of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1β and TNF-alpha. Lisa Allen-Hall, et al. J of Ethnopharmacol. 2007. 109 (2): 312-7
  12. Antimicrobial activity of Uncaria tomentosa against oral human pathogens. Renzo Alberto Ccahuana-Vasquez, et al. Braz Oral Res. 2007.21(1): 46-50.
Updated on 2021/06/01

Use: Joint pain
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DIRECTIONS:

2 capsules per day with half a glass of water at mealtimes.

WARNINGS:

Do not use in case of suffering from stomach or duodenal ulcers or gallstones. Not recommended in case ulcers (stomach or duodenal) of kidney stones. Consult your doctor or pharmacist in case of simultaneous use of anticoagulants. Not recommended for pregnant or lactating women. Do not exceed the recommended daily dose.

ADVICES:

Does not replace a varied and balanced diet and a healthy lifestyle. If you are undergoing medical treatment, seek your therapist's advice. For adult use only. Keep out of reach of young children.

STORAGE INSTRUCTIONS:

Store in a cool dry place away from sunlight.

Updated on 2021/05/31

Quality: Joint pain
loading Consulting batch information

PRODUCT NAME

Joint pain

REFERENCE

SC65

QUANTITY

60 capsules

BATCH NUMBER

D14765

EXPIRATION DATE

2023/05

MADE

In France

SERVINGS PER CONTAINER

30 servings

FABRICATION AND GUARANTEE:

This dietary supplement is manufactured by a GMP-compliant laboratory (GMPs are the good manufacturing practice guidelines for the European pharmaceutical industry).
The active principle content is guaranteed through regular tests.

CHARACTERISTICS:

VEGETABLE CAPSULES

NOT IRRADIATED

WITHOUT ALLERGENS

WITHOUT BPA

NO OMG

WITHOUT LACTOSE

VEGAN

PRODUCT ANALYSIS:

ORGANOLEPTIC QUALITY

SPECIFICATIONS

RESULTS

Appearance:
Powder
Conform with specifications
Colour:
Orangish brown
Conform with specifications
Odour:
Characteristic
Conform with specifications

ANALYTICAL QUALITY

SPECIFICATIONS

RESULTS

Irradiation detection:
Not irradiated
Conform with specifications

MICROBIOLOGICAL QUALITY

SPECIFICATIONS

RESULTS

Plate count:
NMT 10000 cfu/g
Conform with European Pharmacopoeia 8.0
Yeasts and molds:
NMT 100 cfu/g
Conform with European Pharmacopoeia 8.0
E. coli:
Negative
Conform with European Pharmacopoeia 8.0
Salmonella:
Negative
Conform with European Pharmacopoeia 8.0
Enterobacteraceae:
NMT 100 cfu/g
Conform with European Pharmacopoeia 8.0

PRODUCT REGISTRATION:

The notification of placing on the market of this product has been made under notification number PL 2081/36.

HEAD OF THE QUALITY DEPARTMENT

Certificate issue date: 2021/06/01

Updated on 2021/05/31

Reviews and questions: Joint pain

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