Regulator of the biological clock
Guaranteed purity over 99%
Expiration date (End Of): 06/2024 | Ref. AN30
11,50 € (13,80 €)
†N/A: Not applicable
Maltodextrin, vegetable-based capsule: hydroxypropyl methylcellulose.
This product does not contain allergens (in accordance with Regulation (EU) No 1169/2011) nor genetically modified organisms.
Melatonin contributes to the alleviation of subjective feelings of jet lag.
Melatonin contributes to the reduction of time taken to fall asleep.
Melatonin production is highest during adolescence and decreases with age. Therefore, taking melatonin improves sleep quality and helps regulate our biological clock.
Melatonin naturally regulates sleep and has none of the side effects of conventional sleeping pills.
Melatonin relieves tension, relaxes the muscles, is naturally sleep inducing, promotes healthy sleep, diminishes grogginess after sleep and reduces night-time awakenings.
In addition, melatonin helps the body to adapt to changes in its biological clock, which helps to avoid jet-lag in travellers.
Sublingual melatonin acts effectively when rapidly absorbed through the buccal mucosa.
Melatonin: Detailed information
Insomnia is lack of sleep or decreased sleep quality. It is a fairly common disorder that may be due to various causes, such as stress, pathological factors, lifestyle, and it negatively affects the individual’s ability to function during the day. To help regulate the sleep cycle and promote rest, melatonin offers an alternative to traditional sleeping pills.
Melatonin is a hormone produced by the pineal gland from tryptophan and it is regulated by the light-dark cycle. This hormone has several functions: it helps to regulate circadian rhythm and sleep and waking processes, it acts as a neurotransmitter, and also has immunomodulatory and antioxidant properties.
Melatonin’s primary role in the body is regulating day and night cycles, or sleep-wake cycles. Darkness causes the body to produce more melatonin, signalling to the body to prepare for sleep. Conversely, light decreases melatonin production, making the body prepare for waking1.
Melatonin has a chronoregulatory function, to adjust the sleep phase and resynchronise the biological clock2: studies to investigate the effect of melatonin on sleep and circadian rhythm have found a clear link between melatonin and circadian rhythm. Melatonin therefore helps to induce sleep in people whose circadian rhythm is disrupted, and can be used in case of insomnia associated with jet lag and for shift workers3-4.
In addition to its effect on circadian rhythm and the sleep cycle, melatonin has an immunomodulatory and antioxidant function. Its immunomodulatory activity has been demonstrated in in vivo and in vitro studies, where it was seen to act in innate response specifically on the immune system5. Through its antioxidant activity, melatonin stimulates the synthesis of antioxidant enzymes such as superoxide dismutase and glutathione reductase6-7.
- A review of sleep disorders and melatonin. Zizhen Xie, Fei Chen, William A Li, Xiaokun Geng, Changhong Li, Xiaomei Meng, Yan Feng, Wei Liu, Fengchun Yu. Neurol Res. 2017 Jun;39(6):559-565.
- Guía de Práctica Clínica sobre Trastornos del Sueño en la Infancia y Adolescencia en Atención Primaria. 2011. Guías de Práctica Clínica en el SNS: UETS N.º 2009/8
- Role of melatonin in the regulation of human circadian rhythms and sleep. Cajochen et al. J Neuroendocrinol. 2003. 15(4): 432-7.
- Therapeutic applications of melatonin. Kostoglou-Athanassiou. Ther Adv Endocrinol Metab. 2013. 4(1): 13-24.
- Melatonin: buffering the immune system. Carrillo-Vico et al. Int J Mol Sci. 2013. 14(4): 8638-83.
- Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes. Pandi-Perumal et al. Neurotox Res. 2013. 23(3): 267-300.
- Melatonin redox activity. Its potential clinical applications in neurodegenerative disorders. Miller et al. Curr Top Med Chem. 2015. 15(2): 163-9.
2 capsules per day with half a glass of water, half an hour before bedtime.
The beneficial effect is obtained by consuming 1 mg of melatonin close to bedtime. Not recommended for pregnant or lactating women. Do not exceed the recommended daily dose.
Does not replace a varied and balanced diet and a healthy lifestyle. If you are undergoing medical treatment, seek your therapist’s advice. For adult use only. Keep out of reach of young children.
Store in a cool dry place away from sunlight.
SERVINGS PER CONTAINER60 servings
FABRICATION AND GUARANTEE:
This food supplement is manufactured in accordance with GMPs, GMPs are the Good Manufacturing Practices according to current European Pharmaceutical Industry.
The active principle content is guaranteed through regular tests.
Certificate issue date: 2022/07/08
Reviews and questions: Melatonin
great product, bought for my wife who recommended them to her friends , they are all buying them now so well rated. fast postage and kept up to date on delivery.
Fantastic. Have never slept better.
Great product, value and delivery. Have used for a whole now.
3 opinions of 7
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