Organic Maitake (Grifola frondosa)

Standardised extract to contain 30% polysaccharides (15% beta-glucans)

Strengthens the immune system

Organic Maitake (<em>Grifola frondosa</em>)

PRINCIPAL INDICATIONS:

Antioxidant, cancer, cholesterol, diabetes, immunostimulant.

24,00 €

Ref. GN70 In Stock

Description

Maitake (Grifola frondosa (Dicks.: Fr.) S.F. Gray) has been one of the most prized mushrooms in Japan for thousands of years. It is consumed as food and has valuable medicinal properties due to its bioactive compounds.

Rich in nutrients, maitake contains polysaccharides and beta-glucans. These compounds have immunostimulatory properties and help to lower blood glucose levels.

Maitake can help improve and prevent symptoms of obesity, arteriosclerosis and diabetes caused by high cholesterol levels.

Maitake also has heart-healthy properties that help to reduce hypertension and LDL cholesterol levels.

Our organic maitake extract is standardised to contain 30% polysaccharides and 15% beta-glucans, guaranteeing maximum effectiveness.


Detailed information

Maitake: Description and origin

Maitake, grifola or leafy polypore (Grifola frondosa (Dicks.: Fr.) S.F. Gray) is a basidiomycetic fungus used as food as well as in traditional medicine in China and Japan (1). Large in size, maitake grows as a cluster of overlapping layers at the base of trunks or roots of oaks, elms and other trees. It is found in northeastern parts of Japan and also in temperate forests in Asia, Europe and eastern parts of North America (2).

Maitake: History

A mushroom used in the East for thousands of years, the scientific name of maitake (Grifola frondosa) refers to the griffin beast of Greek mythology – half lion, half eagle, while frondosa, means “leaf-like”. In Japanese, mai means to dance and take means mushroom (“dancing mushroom”), because its appearance resembles a butterfly dancing, and because it is said that when people found it they began to jump for joy. It is a very valuable mushroom and it is said that in feudal times it was worth its weight in silver (2).

Maitake: Composition

The maitake mushroom contains beta-glucans, a diverse group of high molecular weight polysaccharides that may constitute between 10-50% of its dry weight. It also contains 5’-nucleotidase, sphingosine ceramides (lipids), aminopeptidases (enzymes), fibre, proteins and microelements (1,3).

Maitake: Our extract

Extract name: Dry extract of organic maitake standardised to contain 30% polysaccharides and 15% beta-glucans

Scientific name: Grifola frondosa (Dicks .: Fr.) S.F. Gray

Part used: Fruiting body

Maitake: Benefits

The maitake mushroom has multiple properties: it has an immunomodulatory effect, reduces blood glucose and lipid levels, as well as acting as a hypotensive and antioxidant. It is also known for its use as an adjuvant in oncological processes (1,3-4).

Maitake: Usage, dosage

A daily dose equivalent to 4 g of fungus is recommended, divided in two doses per day.

Maitake: Studies

The maitake mushroom has immunostimulant properties (4-5). One clinical study in which maitake extract was administered to patients suffering from myelodysplastic syndrome** concluded that beta-glucan extract stimulated immune response to infection by bacteria (6). In another study, combined consumption of shiitake and maitake extracts produced a stimulation of immune response. (7).

Maitake also helps to lower cholesterol levels: it has been established that maitake intake promotes catabolism* of fats and has anti-atherogenic effects (protects against the accumulation of cholesterol in the artery walls) (8) by modulating various enzymes involved in the synthesis, absorption and catabolism of cholesterol (1).

Finally, maitake improves and prevents the symptoms of obesity and diabetes associated with high cholesterol levels (8). In addition, maitake’s polysaccharides help to lower blood glucose levels by improving insulin resistance (9).

 

*Catabolism: set of metabolic processes degrading substances to form simpler ones.

**Myelodysplastic syndrome: syndrome in which immature blood cells in bone marrow do not mature or become healthy blood cells (10).

 

Maitake: Bibliography

1. Ding et al. (2016) The mechanisms underlying the hypolipidaemic effects of Grifola frondosa in the liver of rats. Front Microbiol 7: 1186.

2. Mayell (2001) Maitake extracts and their therapeutic potential – a review. Altern Med Rev 6(1): 48-60.

3. www.fitoterapia.net

4. Guggenheim et al. (2014) Immune modulation from five major mushrooms: application to integrative oncology. Integr Med (Encinitas) 13(1): 32–44.

5. Kodama et al. (2004) Administration of a polysaccharide from Grifola frondosa stimulates immune function of normal mice. J Med Food 7(2): 141-5.

6. Wesa et al. (2015) Maitake mushroom extract in myelodysplastic syndromes (MDS): a phase II study. Cancer Immunol Immunother 64: 237–247.

7. Vetvicka and Vetvickova (2014) Immune-enhancing effects of Maitake (Grifola frondosa) and Shiitake (Lentinula edodes) extracts. Ann Transl Med 2(2): 14.

8. Sato et al. (2013) Plasma cholesterol and transcriptome in mice fed with G. frondosa. J Oleo Sci 62(12): 1049-1058.

9. Xiao et al. (2015) Hypoglycemic effects of Grifola frondosa (Maitake) polysaccharides F2 and F3 through improvement of insulin resistance in diabetic rats. Food Funct 6(11): 3567-75.

10.http://www.cancer.gov/espanol/tipos/mieloproliferativas/paciente/tratamiento-mielodisplasicos-pdq

Composition

INGREDIENTS:

2 capsules contain: 500 mg dry extract of maitake (from organic farming) (Grifola frondosa (Dicks.: Fr.) S.F. Gray) standardised to contain 30% polysaccharides (i.e. 150 mg) and 15% beta-glucans (i.e. 75 mg).

OTHER INGREDIENTS:

Maltodextrin (from organic farming), vegetable-based capsule: hydroxypropyl methylcellulose.

ALLERGENS:

This product does not contain allergens (in accordance with Regulation (EU) No 1169/2011) nor genetically modified organisms.

FABRICATION AND GUARANTEE:

This food supplement is manufactured by a GMP-compliant laboratory (GMPs are the good manufacturing practice guidelines for the European pharmaceutical industry).
Their active principle content is guaranteed through regular tests, which can be viewed online.

Use

DIRECTIONS:

2 capsules per day with half a glass of water in two separate doses, at mealtimes.

WARNINGS:

Not recommended if pregnant or breastfeeding. Do not exceed the recommended daily dose.

ADVICES:

Does not replace a varied and balanced diet and a healthy lifestyle. If you are undergoing medical treatment, seek your therapist's advice. For adult use only. Keep out of reach of young children.

STORAGE INSTRUCTIONS:

Store in a cool dry place away from light.